\u5316\u5b66\u4eff\u5236\u836f\u6709\u673a\u6742\u8d28\u5206\u6790\u548c\u63a7\u5236\u5b9e\u4f8b\u89e3\u6790<\/strong><\/p>\n<\/section>\n<\/section>\n \u6765\u6e90<\/strong><\/p>\n<\/section>\n \u4e2d\u56fd\u65b0\u836f\u6742\u5fd7 2019 \u5e74\u7b2c28 \u5377\u7b2c11 \u671f<\/span><\/p>\n \u5fae\u4fe1\u6392\u7248\uff1a<\/span><\/p>\n<\/section>\n \u4f5c\u8005<\/strong><\/p>\n<\/section>\n \u7ae0\u4fca\u9e9f\uff0c\u4f55\u4f0d<\/p>\n \u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3<\/p>\n<\/section>\n \u6458\u8981<\/strong><\/p>\n<\/section>\n \u5316\u5b66\u836f\u7269\u4e2d\u7684\u6709\u673a\u6742\u8d28\u53c8\u79f0\u6709\u5173\u7269\u8d28\u3002<\/p>\n \u8be5\u7c7b\u6742\u8d28\u901a\u5e38\u4e0e\u6d3b\u6027\u6210\u5206\u5177\u6709\u7c7b\u4f3c\u7684\u5316\u5b66\u7ed3\u6784\uff0c\u5176\u6765\u6e90\u548c\u53bb\u5411\u7684\u5206\u6790\uff0c\u4ee5\u53ca\u51c6\u786e\u548c\u6709\u6548\u7684\u63a7\u5236\uff0c\u662f\u5316\u5b66\u4eff\u5236\u836f\u836f\u5b66\u7814\u7a76\u7684\u5173\u952e\u9879\u76ee\u4e4b\u4e00\u3002<\/p>\n \u672c\u6587\u4ee5\u787c\u66ff\u4f50\u7c73\u3001\u5730\u897f\u4ed6\u6ee8\u548c\u5409\u897f\u4ed6\u6ee8\u4e3a\u4f8b\uff0c\u7ed3\u5408\u539f\u6599\u836f\u7684\u5408\u6210\u65b9\u6cd5\u3001\u5236\u5242\u7684\u5904\u65b9\u5de5\u827a\u548c\u964d\u89e3\u7814\u7a76\uff0c\u5206\u6790\u539f\u6599\u836f\u53ca\u5176\u5236\u5242\u4e2d\u53ef\u80fd\u5b58\u5728\u7684\u6709\u673a\u6742\u8d28\uff0c\u5305\u62ec\u8d77\u59cb\u539f\u6599\u3001\u4e2d\u95f4\u4f53\u3001\u5de5\u827a\u526f\u4ea7\u7269\u3001\u964d\u89e3\u4ea7\u7269\u7b49\uff0c\u5e76\u57fa\u4e8e\u201c\u8d28\u91cf\u6e90\u4e8e\u8bbe\u8ba1\u201d\u7684\u7406\u5ff5\uff0c\u63d0\u51fa\u76f8\u5e94\u7684\u6742\u8d28\u63a7\u5236\u7b56\u7565\uff0c\u5b9e\u73b0\u201c\u5168\u7a0b\u63a7\u5236\u201d\uff0c\u6709\u6548\u786e\u4fdd\u836f\u7269\u7684\u5b89\u5168\u6709\u6548\u548c\u8d28\u91cf\u53ef\u63a7\u3002<\/p>\n<\/section>\n \u5173\u952e\u8bcd<\/strong><\/p>\n<\/section>\n \u6709\u673a\u6742\u8d28; \u8fc7\u7a0b\u63a7\u5236; \u8d28\u91cf\u6e90\u4e8e\u8bbe\u8ba1; \u787c\u66ff\u4f50\u7c73; \u5730\u897f\u4ed6\u6ee8; \u5409\u897f\u4ed6\u6ee8<\/p>\n<\/section>\n \u6b63\u6587 \u5316\u5b66\u836f\u7269\u7684\u6742\u8d28\u662f\u6307\u5b58\u5728\u4e8e\u5316\u5b66\u836f\u7269\u4e2d\u7684\u65e0\u6cbb\u7597\u4f5c\u7528\u6216\u5f71\u54cd\u836f\u7269\u7a33\u5b9a\u6027\u3001\u7597\u6548\uff0c\u751a\u81f3\u5bf9\u4eba\u4f53\u5065\u5eb7\u6709\u5bb3\u7684\u7269\u8d28\u3002<\/p>\n \u4efb\u4f55\u5f71\u54cd\u836f\u7269\u7eaf\u5ea6\u7684\u7269\u8d28\u5747\u53ef\u79f0\u4e3a\u6742\u8d28\u3002<\/p>\n \u6742\u8d28\u7684\u5206\u6790\u548c\u63a7\u5236\u662f\u4fdd\u969c\u7528\u836f\u5b89\u5168\u6709\u6548\u7684\u57fa\u7840\u3002<\/p>\n \u56e0\u6b64\uff0c\u6742\u8d28\u7814\u7a76\u5728\u4eff\u5236\u836f\u836f\u5b66\u7814\u7a76\u4e2d\u5360\u6709\u91cd\u8981\u5730\u4f4d\uff0c\u5176\u662f\u5426\u5f97\u5230\u5168\u9762\u51c6\u786e\u7684\u5206\u6790\u548c\u63a7\u5236\uff0c\u76f4\u63a5\u5173\u7cfb\u5230\u836f\u54c1\u7684\u8d28\u91cf\u53ef\u63a7\u4e0e\u5b89\u5168\u6027\u3002<\/p>\n \u5316\u5b66\u836f\u7269\u4e2d\u7684\u6742\u8d28\u6839\u636e\u5176\u7406\u5316\u6027\u8d28\u4e00\u822c\u53ef\u5206\u4e3a\u6709\u673a\u6742\u8d28\u3001\u65e0\u673a\u6742\u8d28\u548c\u6b8b\u7559\u6eb6\u5242\uff3b1\uff3d\u3002<\/p>\n \u5176\u4e2d\uff0c\u6709\u673a\u6742\u8d28\u53c8\u79f0\u6709\u5173\u7269\u8d28\u3002<\/p>\n \u8fd9\u7c7b\u6742\u8d28\u901a\u5e38\u4e0e\u6d3b\u6027\u6210\u5206\u5177\u6709\u7c7b\u4f3c\u7684\u5316\u5b66\u7ed3\u6784\uff0c\u53ef\u80fd\u5177\u6709\u4e00\u5b9a\u7684\u751f\u7406\u6d3b\u6027\uff0c\u5176\u6765\u6e90\u548c\u53bb\u5411\u7684\u5206\u6790\uff0c\u4ee5\u53ca\u51c6\u786e\u548c\u6709\u6548\u7684\u63a7\u5236\uff0c\u662f\u5316\u5b66\u4eff\u5236\u836f\u8d28\u91cf\u7814\u7a76\u7684\u5173\u952e\u3002<\/p>\n \u672c\u6587\u7ed3\u5408\u8d28\u91cf\u6e90\u4e8e\u8bbe\u8ba1( quality by design\uff0cQbD)\u4ee5\u53ca\u76ee\u524d\u4eff\u5236\u836f\u6742\u8d28\u7814\u7a76\u4e0e\u63a7\u5236\u7684\u4e00\u4e9b\u57fa\u672c\u7406\u5ff5\uff3b2 \uff0d 4\uff3d\uff0c\u4ee5\u787c\u66ff\u4f50\u7c73( bortezomib) \u3001\u5730\u897f\u4ed6\u6ee8( decitabine)\u548c\u5409\u897f\u4ed6\u6ee8( gemcitabine) \u4e3a\u4f8b\uff0c\u7ed3\u5408\u5316\u5408\u7269\u7ed3\u6784\u7279\u70b9\u3001\u539f\u6599\u836f\u5408\u6210\u8def\u7ebf\u3001\u5236\u5242\u5904\u65b9\u5de5\u827a\u3001\u964d\u89e3\u9014\u5f84\u548c\u76f8\u5173\u6587\u732e\u8d44\u6599\uff0c\u5bf9\u5176\u6709\u673a\u6742\u8d28\u8fdb\u884c\u5206\u6790\uff0c\u5e76\u63a2\u8ba8\u76f8\u5e94\u7684\u6742\u8d28\u63a7\u5236\u7b56\u7565\uff0c\u4ee5\u671f\u4e3a\u4eff\u5236\u836f\u7684\u6742\u8d28\u7814\u7a76\u5de5\u4f5c\u63d0\u4f9b\u53c2\u8003\u601d\u8def\u3002<\/p>\n \u9700\u8981\u6307\u51fa\u7684\u662f\uff0c\u672c\u6587\u4e0d\u5bf9\u9057\u4f20\u6bd2\u6027\u6742\u8d28\u7b49\u9ad8\u6bd2\u6027\u7269\u8d28\u8fdb\u884c\u8ba8\u8bba\uff0c\u53ef\u53c2\u7167\u76f8\u5173\u6307\u5bfc\u539f\u5219\u7814\u7a76\u3002<\/p>\n<\/section>\n 1<\/p>\n<\/section>\n<\/section>\n<\/section>\n \u5de5\u827a\u6742\u8d28\u7684\u5206\u6790\u548c\u63a7\u5236<\/strong><\/p>\n<\/section>\n<\/section>\n \u539f\u6599\u836f\u7684\u5de5\u827a\u6742\u8d28\u53ef\u80fd\u6765\u6e90\u4e8e\u8d77\u59cb\u539f\u6599\u3001\u8d77\u59cb\u539f\u6599\u5f15\u5165\u7684\u6742\u8d28\u53ca\u5176\u540e\u7eed\u53cd\u5e94\u7269\u3001\u4e2d\u95f4\u4f53\u3001\u526f\u53cd\u5e94\u4ea7\u7269\u53ca\u5176\u540e\u7eed\u53cd\u5e94\u7269\u3001\u53cd\u5e94\u4e2d\u4f7f\u7528\u7684\u6709\u673a\u8bd5\u5242\u7b49\u3002\u73b0\u4ee5\u787c\u66ff\u4f50\u7c73\u4e3a\u4f8b\uff0c\u7ed3\u5408\u5176\u5236\u5907\u5de5\u827a\uff0c\u63a2\u8ba8\u539f\u6599\u836f\u5de5\u827a\u6742\u8d28\u7684\u5206\u6790\u53ca\u5176\u63a7\u5236\u7b56\u7565\u3002<\/p>\n \u787c\u66ff\u4f50\u7c73\uff0c\u5316\u5b66\u540d\u79f0\u4e3a\uff3b( 1\uff32) -3-\u7532\u57fa-1-\uff3b\uff3b( 2S) -1-\u6c27-3-\u82ef\u57fa-2-\uff3b( \u5421\u55ea\u7fa7\u57fa) \u6c28\u57fa\uff3d\u4e19\u57fa\uff3d\u6c28\u57fa\uff3d\u4e01\u57fa\uff3d\u787c\u9178\uff0c\u7531\u5343\u79a7( Millennium) \u5236\u836f( \u540e\u88ab\u65e5\u672c\u6b66\u7530\u5236\u836f\u516c\u53f8\u6536\u8d2d) \u548c\u5f3a\u751f\u5171\u540c\u5f00\u53d1\uff0c\u662f\u5168\u7403\u4e0a\u5e02\u7684\u7b2c\u4e00\u4e2a\u5408\u6210\u7684\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\uff0c\u4e3a\u9776\u5411\u6cbb\u7597\u7684\u65b0\u578b\u6297\u764c\u836f\u3002<\/p>\n \u787c\u66ff\u4f50\u7c73\u539f\u6599\u836f\u5728\u56fa\u4f53\u72b6\u6001\u4e0b\u4ee5\u4e09\u805a\u4f53\u5f62\u5f0f( \u65e0\u6c34\u4e09\u805a\u73af\u787c\u6c27\u70f7\u9178\u9150\u7ed3\u6784) \u5b58\u5728\uff0c\u5728\u6c34\u6eb6\u6db2\u4e2d\u89e3\u79bb\u4e3a\u5355\u4f53\uff0c\u5e76\u4e0e\u4e09\u805a\u4f53\u5e73\u8861\u5b58\u5728\uff3b5\uff3d( \u89c1\u56fe1)<\/p>\n \u5176\u5236\u5242\u6ce8\u5c04\u7528\u787c\u66ff\u4f50\u7c73\u4e8e2003 \u5e74\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2004 \u5e74\u5728\u6b27\u6d32\u4e0a\u5e02\uff0c2005 \u5e74\u83b7\u51c6\u8fdb\u53e3\u4e2d\u56fd\uff0c\u5546\u54c1\u540d\u201cVelcade \/\u4e07\u73c2\u201d\uff0c\u7528\u4e8e\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u548c\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u3002<\/p>\n 2015 \u5e7410 \u6708\u787c\u66ff\u4f50\u7c73\u5316\u5408\u7269\u4e13\u5229\u5230\u671f\uff0c\u6ce8\u5c04\u7528\u787c\u66ff\u4f50\u7c73\u968f\u5373\u6210\u4e3a\u56fd\u5185\u5316\u5b66\u836f\u7269\u4eff\u5236\u836f\u7533\u62a5\u7684\u70ed\u70b9\u54c1\u79cd\u4e4b\u4e00\u3002<\/p>\n \u56fd\u5185\u5916\u5747\u6709\u62a5\u9053\u787c\u66ff\u4f50\u7c73\u7684\u5408\u6210\u548c\u5236\u5907\u5de5\u827a\uff3b6 \uff0d 7\uff3d\uff0c\u901a\u8fc7\u603b\u7ed3\u5206\u6790\uff0c\u5b9e\u9645\u5236\u5907\u91c7\u7528\u7684\u5408\u6210\u8def\u7ebf\u6bd4\u8f83\u4e00\u81f4\uff0c\u5373\u5728\u539f\u7814\u5316\u5408\u7269\u4e13\u5229\u8def\u7ebf\u7684\u57fa\u7840\u4e0a\uff3b8\uff3d\uff0c\u4ee5L-\u787c\u4eae\u6c28\u9178\u848e\u70f7\u4e8c\u9187\u916f\u4e3a\u8d77\u59cb\u539f\u6599\uff0c\u9996\u5148\u4e0e\u6c28\u57fa\u4fdd\u62a4\u7684L-\u82ef\u4e19\u6c28\u9178\u7f29\u5408\uff0c\u518d\u8131\u4fdd\u62a4\u540e\u4e0e2-\u7532\u9178\u5421\u55ea\u7f29\u5408\uff0c\u5f62\u6210\u787c\u66ff\u4f50\u7c73\u848e\u70f7\u4e8c\u9187\u916f\uff0c\u7136\u540e\u5728\u5f02\u4e01\u57fa\u787c\u9178\u6761\u4ef6\u4e0b\u8131\u848e\u70f7\u4fdd\u62a4\u57fa\u83b7\u5f97\u787c\u66ff\u4f50\u7c73\u7c97\u54c1\uff0c\u7cbe\u5236\uff0c\u5373\u5f97\u787c\u66ff\u4f50\u7c73\u539f\u6599\u836f\u3002<\/p>\n \u6216\u4ee5L-\u787c\u4eae\u6c28\u9178\u848e\u70f7\u4e8c\u9187\u916f\u4e3a\u8d77\u59cb\u539f\u6599\uff0c\u76f4\u63a5\u4e0eN-\u5421\u55ea\u7fb0\u57fa-L-\u82ef\u4e19\u6c28\u9178\u7f29\u5408\u5f62\u6210\u787c\u66ff\u4f50\u7c73\u848e\u70f7\u4e8c\u9187\u916f\uff0c\u518d\u8131\u4fdd\u62a4\u83b7\u5f97\u787c\u66ff\u4f50\u7c73\u7c97\u54c1\uff0c\u7cbe\u5236\uff0c\u5f97\u5230\u787c\u66ff\u4f50\u7c73\uff0c\u89c1\u56fe2\u3002<\/p>\n 1.1 \u8d77\u59cb\u539f\u6599\u53ca\u5176\u5f15\u5165\u6742\u8d28<\/strong><\/p>\n<\/section>\n \u7ed3\u5408\u5de5\u827a\u8def\u7ebf\uff0c\u787c\u66ff\u4f50\u7c73\u4e3b\u8981\u8d77\u59cb\u539f\u6599\u5305\u62ecL-\u787c\u4eae\u6c28\u9178\u848e\u70f7\u4e8c\u9187\u916f\u3001N-\u5421\u55ea\u7fb0\u57fa-L-\u82ef\u4e19\u6c28\u9178\u6216\u6c28\u57fa\u4fdd\u62a4\u7684\u82ef\u4e19\u6c28\u9178\u548c2-\u7532\u9178\u5421\u55ea\u3002<\/p>\n L-\u787c\u4eae\u6c28\u9178\u848e\u70f7\u4e8c\u9187\u916f\u4e00\u822c\u7531\u5f02\u4e01\u57fa\u787c\u9178\u548c\u848e\u70f7\u4e8c\u9187\u53cd\u5e94\u751f\u6210\u5f02\u4e01\u57fa\u787c\u9178\u848e\u70f7\u4e8c\u9187\u916f\u540e\uff0c\u7ecf\u5364\u4ee3\u3001\u6c28\u57fa\u53d6\u4ee3\u83b7\u5f97\uff0c\u901a\u5e38\u4f7f\u7528\u5176\u4e09\u6c1f\u4e59\u9178\u76d0\u3002<\/p>\n \u7ed3\u5408\u5236\u5907\u5de5\u827a\uff0c\u5176\u4e3b\u8981\u6709\u673a\u6742\u8d28\u5305\u62ec: \u8d77\u59cb\u7269\u6599\u848e\u70f7\u4e8c\u9187\u548c\u5f02\u4e01\u57fa\u787c\u9178\uff0c\u4e2d\u95f4\u4f53\u5f02\u4e19\u57fa\u787c\u9178\u848e\u70f7\u4e8c\u9187\u916f\u3001\u5364\u4ee3\u7269\uff0c\u5f02\u6784\u4f53\u6742\u8d28D-\u787c\u4eae\u6c28\u9178\u848e\u70f7\u4e8c\u9187\u916f\uff0c\u4ee5\u53ca\u53ef\u80fd\u964d\u89e3\u4ea7\u751f\u7684\u5f02\u620a\u80fa\u7b49\u3002<\/p>\n \u8be5\u8d77\u59cb\u539f\u6599\u7684\u624b\u6027\u4e2d\u5fc3\u5c06\u76f4\u63a5\u5e26\u5165\u6210\u54c1\uff0c\u5176\u5f02\u6784\u4f53\u6742\u8d28\u53ef\u80fd\u7ee7\u7eed\u53cd\u5e94\u751f\u6210\u6210\u54c1\u5bf9\u6620\u5f02\u6784\u4f53\uff32\uff0cS-\u787c\u66ff\u4f50\u7c73\u548c\u975e\u5bf9\u6620\u5f02\u6784\u4f53S\uff0cS-\u787c\u66ff\u4f50\u7c73\uff0c\u56e0\u6b64\u5f02\u6784\u4f53\u6742\u8d28\u5e94\u4f5c\u4e3a\u5173\u952e\u8d28\u63a7\u9879\u3002<\/p>\n N-\u5421\u55ea\u7fb0\u57fa-L-\u82ef\u4e19\u6c28\u9178\u901a\u5e38\u7531L-\u82ef\u4e19\u6c28\u9178\u6210\u916f( \u5982\uff0c\u7532\u916f\u3001\u4e09\u7532\u57fa\u7845\u916f) \u540e\u4e0e2-\u7532\u9178\u5421\u55ea\u53cd\u5e94\u83b7\u5f97\u3002<\/p>\n \u7ed3\u5408\u5236\u5907\u5de5\u827a\uff0c\u5206\u6790\u5176\u4e3b\u8981\u6709\u673a\u6742\u8d28\u5305\u62ec: \u8d77\u59cb\u7269\u6599L-\u82ef\u4e19\u6c28\u9178\u548c2-\u7532\u9178\u5421\u55ea\uff0c\u4e2d\u95f4\u4f53L-\u82ef\u4e19\u6c28\u9178\u916f\uff0c\u526f\u4ea7\u7269\u82ef\u4e19\u6c28\u9178\u4e8c\u805a\u4f53\uff0c\u4ee5\u53ca\u5f02\u6784\u4f53\u6742\u8d28N-\u5421\u55ea\u7fb0\u57fa-D-\u82ef\u4e19\u6c28\u9178\u7b49\u3002<\/p>\n \u8be5\u7269\u6599\u7684\u624b\u6027\u4e2d\u5fc3\u4e5f\u76f4\u63a5\u5e26\u5165\u6210\u54c1\uff0c\u5f02\u6784\u4f53\u6742\u8d28\u5e94\u4f5c\u4e3a\u5173\u952e\u6742\u8d28\u63a7\u5236\u3002<\/p>\n \u5de5\u827a\u4e2d\u5e38\u7528\u7684\u6c28\u57fa\u4fdd\u62a4\u7684\u82ef\u4e19\u6c28\u9178\u4e3aN-\u53d4\u4e01\u6c27\u7fb0\u57fa-L-\u82ef\u4e19\u6c28\u9178\uff0c\u7531L-\u82ef\u4e19\u6c28\u9178\u4e0eBoc \u9178\u9150\u9170\u5316\u53cd\u5e94\u83b7\u5f97\uff0c\u5176\u5f02\u6784\u4f53\u4e5f\u5e94\u4f5c\u4e3a\u5173\u952e\u6742\u8d28\u63a7\u5236\u3002<\/p>\n 2-\u7532\u9178\u5421\u55ea\u5de5\u827a\u8f83\u4e3a\u6210\u719f\uff0c\u53ef\u75312-\u6c30\u57fa\u5421\u55ea\u6c27\u5316\u6216\u5421\u55ea\u4e8c\u7fa7\u9178\u8131\u7fa7\u5236\u5f97\uff0c\u5176\u53ef\u80fd\u5b58\u5728\u7684\u6742\u8d28\u5305\u62ec\u8d77\u59cb\u7269\u6599\u548c\u5421\u55ea\u7fa7\u9178\u916f\u3002<\/p>\n \u787c\u66ff\u4f50\u7c73\u7ed3\u6784\u8f83\u4e3a\u590d\u6742\uff0c\u8d77\u59cb\u539f\u6599\u672c\u8eab\u4e5f\u662f\u6210\u54c1\u91cd\u8981\u7684\u5de5\u827a\u6742\u8d28\u3002\u540c\u65f6\uff0c\u848e\u70f7\u7ed3\u6784\u5728\u5236\u836f\u884c\u4e1a\u4f7f\u7528\u76f8\u5bf9\u8f83\u5c11\uff0c\u4e14\u6210\u54c1\u624b\u6027\u4e2d\u5fc3\u5747\u7531\u8d77\u59cb\u7269\u6599\u5f15\u5165\u3002<\/p>\n \u56e0\u6b64\uff0c\u57fa\u4e8e\u6e90\u5934\u63a7\u5236\u7684\u7406\u5ff5\uff0c\u539f\u6599\u836f\u751f\u4ea7\u4f01\u4e1a\u5982\u91c7\u7528\u5916\u8d2d\u8d77\u59cb\u539f\u6599\uff0c\u5e94\u4e25\u683c\u8fdb\u884c\u4f9b\u5e94\u5546\u7b5b\u9009\u548c\u5ba1\u8ba1\uff0c\u5145\u5206\u7406\u89e3\u4f9b\u5e94\u5546\u7684\u5236\u5907\u5de5\u827a\uff0c\u5e76\u7ed3\u5408\u81ea\u8eab\u5de5\u827a\u7279\u70b9\uff0c\u5206\u6790\u8d77\u59cb\u539f\u6599\u7684\u5173\u952e\u8d28\u91cf\u5c5e\u6027\uff0c\u7279\u522b\u662f\u8d77\u59cb\u539f\u6599\u53ca\u5176\u6742\u8d28\u5728\u540e\u7eed\u5de5\u827a\u8fc7\u7a0b\u4e2d\u7684\u8f6c\u5316\u548c\u53bb\u9664\u60c5\u51b5\uff0c\u9488\u5bf9\u6027\u5730\u5efa\u7acb\u8d77\u59cb\u7269\u6599\u7684\u5185\u63a7\u6807\u51c6\u3002<\/p>\n<\/section>\n 1. 2 \u5de5\u827a\u4e2d\u95f4\u4f53\u53ca\u526f\u4ea7\u7269<\/strong><\/p>\n<\/section>\n \u787c\u66ff\u4f50\u7c73\u7684\u5173\u952e\u4e2d\u95f4\u4f53\u4e3a\u787c\u66ff\u4f50\u7c73\u848e\u70f7\u4e8c\u9187\u916f\u3002<\/p>\n \u4ece\u7ed3\u6784\u548c\u53cd\u5e94\u673a\u7406\u5206\u6790\uff0cN-\u53d4\u4e01\u6c27\u7fb0\u57fa-L-\u82ef\u4e19\u6c28\u9178\u5728\u53cd\u5e94\u4e2d\u53ef\u80fd\u53d1\u751f\u82ef\u4e19\u6c28\u9178\u6d88\u65cb\uff0c\u56e0\u6b64\uff0c\u4e2d\u95f4\u4f53\u7814\u7a76\u8fc7\u7a0b\u4e2d\u4ecd\u5e94\u8fdb\u884c\u5f02\u6784\u4f53\u6742\u8d28\u7684\u7814\u7a76\u548c\u63a7\u5236\u3002<\/p>\n \u787c\u66ff\u4f50\u7c73\u5de5\u827a\u8def\u7ebf\u4e2d\u53ef\u80fd\u4ea7\u751f\u7684\u526f\u4ea7\u7269\u6709\u5f02\u4e01\u57fa\u787c\u9178\u848e\u70f7\u4e8c\u9187\u916f\u3001\u82ef\u4e19\u6c28\u9178\u4e8c\u805a\u4f53\u7b49\uff3b9\uff3d\uff0c\u7ed3\u6784\u5f0f\u89c1\u56fe3\u3002<\/p>\n \u5bf9\u4e8e\u4e2d\u95f4\u4f53\u548c\u526f\u4ea7\u7269\u7b49\u6742\u8d28\uff0c\u5e94\u5145\u5206\u4f53\u73b0\u8fc7\u7a0b\u63a7\u5236\u7684\u7406\u5ff5\uff0c\u9009\u62e9\u5408\u7406\u7684\u5de5\u827a\u8def\u7ebf\uff0c\u5728\u660e\u786e\u6742\u8d28\u7ed3\u6784\u7684\u57fa\u7840\u4e0a\uff0c\u5bf9\u6295\u6599\u6bd4\u3001\u5173\u952e\u7f29\u5408\u8bd5\u5242\u3001\u53cd\u5e94\u6db2\u6d53\u5ea6\u3001\u6e29\u5ea6\u3001\u65f6\u95f4\u3001\u6eb6\u5242\u7b49\u5de5\u827a\u53c2\u6570\u8fdb\u884c\u7b5b\u9009\u7814\u7a76\uff0c\u786e\u5b9a\u5408\u7406\u7684\u5173\u952e\u5de5\u827a\u6b65\u9aa4\u53ca\u53c2\u6570\u8303\u56f4\uff0c\u5e76\u5728\u5546\u4e1a\u5316\u751f\u4ea7\u8f6c\u5316\u8fc7\u7a0b\u4e2d\uff0c\u5728\u4e00\u5b9a\u751f\u4ea7\u89c4\u6a21\u4e0b\u8fdb\u884c\u5de5\u827a\u9a8c\u8bc1\uff0c\u786e\u4fdd\u5927\u751f\u4ea7\u5de5\u827a\u7684\u53ef\u884c\u6027\u548c\u91cd\u73b0\u6027\u3002<\/p>\n<\/section>\n 1. 3 \u6709\u673a\u8bd5\u5242\u53ca\u5176\u8f6c\u5316\u7269<\/strong><\/p>\n<\/section>\n \u787c\u66ff\u4f50\u7c73\u7684\u5408\u6210\u53ca\u5176\u8d77\u59cb\u539f\u6599\u7684\u5236\u5907\u8fc7\u7a0b\u4e2d\u5747\u4f7f\u7528\u8f83\u591a\u79cd\u7c7b\u7684\u6709\u673a\u8bd5\u5242\uff0c\u5982\uff0cL-\u787c\u4eae\u6c28\u9178\u848e\u70f7\u4e8c\u9187\u916f\u5408\u6210\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u4f7f\u7528\u4e8c\u5f02\u4e19\u57fa\u6c28\u57fa\u9502( LDA) \u3001\u516d\u7532\u57fa\u4e8c\u7845\u57fa\u6c28\u57fa\u9502( Li-HMDS) ; N-\u5421\u55ea\u7fb0\u57fa-L-\u82ef\u4e19\u6c28\u9178\u5408\u6210\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u4f7f\u7528N\uff0cO-\u53cc\u4e09\u7532\u57fa\u7845\u57fa\u4e59\u9170\u80fa; \u787c\u66ff\u4f50\u7c73\u4e2d\u95f4\u4f53\u53ca\u7c97\u54c1\u5408\u6210\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u4f7f\u7528\u5f02\u4e01\u57fa\u787c\u9178\u30011-\u7f9f\u57fa\u82ef\u5e76\u4e09\u5511( HOBt) \u3001\u78b3\u5316\u4e8c\u4e9a\u80fa( DCC\uff0cDIC\uff0cEDCI) \u3001N\uff0cN-\u4e8c\u5f02\u4e19\u57fa\u4e59\u57fa\u80fa( DIEA\uff0cDIPEA) \u3001O-\u82ef\u5e76\u4e09\u6c2e\u5511-N\uff0cN\uff0cN’\uff0cN’-\u56db\u7532\u57fa\u8132\u56db\u6c1f\u787c\u9178\u916f( TBTU) \u3001O-( 7-\u6c2e\u6742\u82ef\u5e76\u4e09\u6c2e\u5511) -N\uff0cN\uff0cN’\uff0cN’-\u56db\u7532\u57fa\u8132\u56db\u6c1f\u787c\u9178\u76d0( TATU)\u7b49\u3002<\/p>\n \u5e94\u5bf9\u8fd9\u4e9b\u6709\u673a\u8bd5\u5242\u53ca\u5176\u8f6c\u5316\u4ea7\u7269\u7684\u6765\u6e90\u548c\u53bb\u5411\u8fdb\u884c\u5206\u6790\u7814\u7a76\uff0c\u79ef\u7d2f\u5145\u5206\u7684\u6570\u636e\uff0c\u5236\u5b9a\u5408\u7406\u7684\u63a7\u5236\u7b56\u7565\u3002<\/p>\n<\/section>\n 2<\/p>\n<\/section>\n<\/section>\n<\/section>\n \u964d\u89e3\u6742\u8d28\u7684\u5206\u6790\u548c\u63a7\u5236<\/strong><\/p>\n<\/section>\n<\/section>\n \u964d\u89e3\u6742\u8d28\u4e0e\u5316\u5408\u7269\u7ed3\u6784\u7279\u5f81\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n \u539f\u6599\u836f\u5e94\u5728\u5206\u6790\u964d\u89e3\u6742\u8d28\u4ea7\u751f\u673a\u7406\u7684\u57fa\u7840\u4e0a\u4f18\u5316\u5de5\u827a\u53c2\u6570\uff0c\u5e76\u9488\u5bf9\u654f\u611f\u56e0\u7d20\u9009\u62e9\u9002\u5b9c\u7684\u5305\u88c5\uff0c\u7ed3\u5408\u7a33\u5b9a\u6027\u7814\u7a76\u7ed3\u679c\u62df\u5b9a\u5408\u7406\u7684\u8d2e\u85cf\u6761\u4ef6\u3002<\/p>\n \u5236\u5242\u5e94\u91cd\u70b9\u63a7\u5236\u964d\u89e3\u6742\u8d28\uff0c\u5bf9\u4e8e\u5df2\u5728\u539f\u6599\u836f\u4e2d\u63a7\u5236\u7684\u5de5\u827a\u6742\u8d28\u5728\u5236\u5242\u4e2d\u53ef\u4e0d\u7528\u518d\u63a7\u5236\uff3b10\uff3d\u3002<\/p>\n \u73b0\u4ee5\u5730\u897f\u4ed6\u6ee8\u4e3a\u4f8b\uff0c\u63a2\u8ba8\u5236\u5242\u6709\u673a\u6742\u8d28\u7684\u5206\u6790\u601d\u8def\u53ca\u5176\u63a7\u5236\u7b56\u7565\u3002<\/p>\n \u5730\u897f\u4ed6\u6ee8\uff0c\u5316\u5b66\u540d\u79f0\u4e3a4-\u6c28\u57fa-1-( 2-\u8131\u6c27-\u03b2-D-\u8d64\u5f0f-\u544b\u5583\u6838\u7cd6) -1\uff0c3\uff0c5-\u4e09\u55ea-2 ( 1H) -\u916e\uff0c\u7531\u7f8e\u56fdMGI Pharma \u516c\u53f8\u5f00\u53d1\u4e0a\u5e02\uff0c\u4e3a\u80de\u5627\u5576\u6838\u82f7\u7c7b\u4f3c\u7269\uff0c\u5e72\u6270DNA \u5408\u6210\u5f15\u8d77\u7ec6\u80de\u51cb\u4ea1\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u5176\u5236\u5242\u6ce8\u5c04\u7528\u5730\u897f\u4ed6\u6ee8\u4e8e2006 \u5e74\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2008\u5e74\u5728\u4e2d\u56fd\u4e0a\u5e02\uff0c2012 \u5e74\u83b7\u51c6\u5728\u6b27\u6d32\u4e0a\u5e02\uff0c\u5546\u54c1\u540d\u201cDacogen \/\u8fbe\u73c2\u201d\uff0c\u7528\u4e8e\u6cbb\u7597\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\u3002<\/p>\n \u76ee\u524d\u56fd\u5185\u5df2\u67097 \u5bb6\u4f01\u4e1a\u751f\u4ea7\u7684\u4eff\u5236\u836f\u6279\u51c6\u4e0a\u5e02\u3002<\/p>\n \u5730\u897f\u4ed6\u6ee8\u7a33\u5b9a\u6027\u8f83\u5dee\uff0c\u964d\u89e3\u6742\u8d28\u8f83\u591a\uff0c\u5c24\u5176\u5bf9\u6c34\u654f\u611f\uff0c\u7ed3\u5408\u6587\u732e\u8d44\u6599\u5206\u6790\u5176\u6f5c\u5728\u964d\u89e3\u6742\u8d28\u89c1\u56fe4<\/p>\n \u5236\u5242\u7814\u7a76\u8fc7\u7a0b\u4e2d\uff0c\u5e94\u4ee5\u654f\u611f\u6742\u8d28\u4e3a\u8003\u5bdf\u5bf9\u8c61\uff0c\u5bf9\u6eb6\u6db2\u914d\u5236\u65f6\u539f\u8f85\u6599\u52a0\u5165\u987a\u5e8f\u3001\u6eb6\u89e3\u65f6\u95f4\u548c\u6e29\u5ea6\u8fdb\u884c\u4f18\u5316\uff0c\u5bf9\u9664\u83cc\u8fc7\u6ee4\u65f6\u95f4\u548c\u6e29\u5ea6\u7b49\u5de5\u827a\u8fc7\u7a0b\u63a7\u5236\u53c2\u6570\u8fdb\u884c\u7814\u7a76\uff0c\u786e\u5b9a\u5408\u7406\u7684\u51bb\u5e72\u5de5\u827a\u53c2\u6570\u3002<\/p>\n \u540c\u65f6\uff0c\u8fd8\u5e94\u8003\u8651\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u662f\u5426\u9700\u8981\u907f\u5149\u64cd\u4f5c\u548c\u5145\u6c2e\u4fdd\u62a4\uff0c\u4ee5\u5c3d\u91cf\u51cf\u5c11\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u964d\u89e3\u6742\u8d28\u7684\u4ea7\u751f\uff0c\u5e76\u5728\u5927\u751f\u4ea7\u89c4\u6a21\u4e0b\u786e\u5b9a\u5de5\u827a\u7684\u53ef\u884c\u6027\u548c\u91cd\u73b0\u6027\u3002\u901a\u8fc7\u7ec6\u81f4\u7684\u7814\u7a76\u5de5\u4f5c\uff0c\u5145\u5206\u7406\u89e3\u5236\u5242\u5904\u65b9\u5de5\u827a\u7279\u70b9\uff0c\u4ece\u6e90\u5934\u4e0a\u5bf9\u539f\u6599\u836f\u548c\u5173\u952e\u8f85\u6599\u63d0\u51fa\u8d28\u91cf\u8981\u6c42\uff0c\u660e\u786e\u5173\u952e\u5de5\u827a\u53c2\u6570\u53ca\u5176\u63a7\u5236\u8303\u56f4\uff0c\u62df\u5b9a\u5408\u7406\u7684\u4e2d\u95f4\u4f53\u8d28\u63a7\u6807\u51c6\uff0c\u5e76\u7ed3\u5408\u8d28\u91cf\u7814\u7a76\u548c\u7a33\u5b9a\u6027\u7814\u7a76\u7ed3\u679c\u9009\u62e9\u5408\u7406\u7684\u5305\u88c5\uff0c\u786e\u5b9a\u8d2e\u85cf\u6761\u4ef6\u3002<\/p>\n \u4f5c\u4e3a\u4eff\u5236\u836f\uff0c\u8fd8\u5e94\u4e0e\u591a\u6279\u6b21\u7684\u539f\u7814\u54c1\u8fdb\u884c\u5168\u9762\u7684\u6742\u8d28\u8c31\u5bf9\u6bd4\u7814\u7a76\uff0c\u539f\u5219\u4e0a\u4eff\u5236\u54c1\u7684\u6742\u8d28\u79cd\u7c7b\u548c\u542b\u91cf\u5747\u5e94\u4e0d\u8d85\u8fc7\u539f\u7814\u54c1\uff0c\u7279\u522b\u662f\u4eff\u5236\u54c1\u51fa\u73b0\u8d85\u8fc7\u9274\u5b9a\u9650\u5ea6\u7684\u65b0\u6742\u8d28\u65f6\uff0c\u5e94\u5145\u5206\u5206\u6790\u5176\u4ea7\u751f\u539f\u56e0\uff0c\u91c7\u53d6\u76f8\u5e94\u63aa\u65bd\uff0c\u964d\u4f4e\u6742\u8d28\u542b\u91cf\uff0c\u4ee5\u786e\u4fdd\u4eff\u5236\u836f\u8d28\u91cf\u4e0d\u4f4e\u4e8e\u539f\u7814\u54c1\u3002<\/p>\n<\/section>\n 3<\/p>\n<\/section>\n<\/section>\n<\/section>\n \u4e0a\u5e02\u540e\u836f\u7269\u6742\u8d28\u63a7\u5236\u7684\u7ba1\u7406<\/strong><\/p>\n<\/section>\n<\/section>\n \u4e0a\u8ff02 \u4e2a\u5b9e\u4f8b\u4e3b\u8981\u9610\u8ff0\u836f\u54c1\u7814\u53d1\u8fc7\u7a0b\u4e2d\u5bf9\u4e8e\u5de5\u827a\u6742\u8d28\u548c\u964d\u89e3\u6742\u8d28\u7684\u8003\u8651\uff0c\u5bf9\u4e8e\u5df2\u4e0a\u5e02\u836f\u54c1\uff0c\u968f\u7740\u79d1\u5b66\u7684\u53d1\u5c55\u548c\u8ba4\u8bc6\u7684\u52a0\u6df1\uff0c\u6216\u4e34\u5e8a\u8fd0\u7528\u4e2d\u51fa\u73b0\u4e86\u53ef\u80fd\u7531\u6742\u8d28\u5f15\u53d1\u7684\u95ee\u9898\uff0c\u63d0\u793a\u6211\u4eec\u5e94\u66f4\u65b0\u5bf9\u8be5\u836f\u54c1\u7684\u6742\u8d28\u63a7\u5236\uff0c\u5373\u836f\u54c1\u6742\u8d28\u7684\u5168\u751f\u547d\u5468\u671f\u7ba1\u7406\u3002<\/p>\n \u76ee\u524dICHQ12 \u5df2\u63d0\u51fa\u4e86\u836f\u54c1\u751f\u547d\u5468\u671f\u7ba1\u7406\u4e2d\u7684\u6280\u672f\u548c\u6cd5\u89c4\u8003\u8651\uff3b13\uff3d\u3002<\/p>\n \u73b0\u4ee5\u5409\u897f\u4ed6\u6ee8\u4e3a\u4f8b\uff0c\u7b80\u8981\u63a2\u8ba8\u4e0a\u5e02\u540e\u836f\u54c1\u6742\u8d28\u63a7\u5236\u7684\u53d8\u66f4\u3002\u76d0\u9178\u5409\u897f\u4ed6\u6ee8\uff0c\u53732′-\u8131\u6c27-2’\uff0c2′-\u4e8c\u6c1f\u80de\u82f7( \u03b2-\u5f02\u6784\u4f53) \u76d0\u9178\u76d0\uff0c\u7531\u793c\u6765\u516c\u53f8\u5f00\u53d1\uff0c\u4e3a\u6297\u4ee3\u8c22\u7c7b\u6297\u80bf\u7624\u836f\uff0c\u5176\u5236\u5242\u6ce8\u5c04\u7528\u76d0\u9178\u5409\u897f\u4ed6\u6ee8\u4e8e1995 \u5e74\u9996\u6b21\u5728\u82f1\u56fd\u7b49\u6b27\u6d32\u56fd\u5bb6\u4e0a\u5e02\uff0c1996 \u5e74\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c1999 \u5e74\u6279\u51c6\u8fdb\u53e3\u6211\u56fd\uff0c\u5546\u54c1\u540d\u201cGemzar \/\u5065\u62e9\u201d\uff0c\u53ef\u5355\u836f\u6216\u8054\u5408\u7528\u836f\u6cbb\u7597\u591a\u79cd\u764c\u75c7\uff0c\u73b0\u5df2\u8fdb\u5165\u56fd\u5bb6\u533b\u4fdd\u3002<\/p>\n \u8fd1\u5e74\u6765\u7814\u7a76\u53d1\u73b0\uff0c\u76d0\u9178\u5409\u897f\u4ed6\u6ee8\u4f53\u5185\u65e0\u6d3b\u6027\u7684\u4e3b\u8981\u4ee3\u8c22\u7269\u03b2-\u5c3f\u82f7( \u03b2-uridine) \uff0c\u4e3a\u5176\u4e3b\u8981\u964d\u89e3\u6742\u8d28\uff0c\u9178\u3001\u78b1\u3001\u70ed\u7b49\u591a\u79cd\u6761\u4ef6\u4e0b\u5747\u53ef\u80fd\u964d\u89e3\u4ea7\u751f\uff0c\u5c24\u5176\u662f\u5728\u6c34\u6eb6\u6db2\u4e2d\uff3b14 \uff0d 15\uff3d\u3002<\/p>\n \u82f1\u56fd\u836f\u51782013 \u5e74\u7248\u76d0\u9178\u5409\u897f\u4ed6\u6ee8\u6807\u51c6\u4e2d\u4ec5\u63a7\u5236\u5df2\u77e5\u6742\u8d28\u80de\u5627\u5576\uff0c\u5728\u82f1\u56fd\u836f\u51782016 \u5e74\u7248\u4e2d\u5219\u589e\u52a0\u4e86\u5df2\u77e5\u6742\u8d28\u03b2-\u5c3f\u82f7\u7684\u63a7\u5236\u3002<\/p>\n \u7ed3\u6784\u5f0f\u89c1\u56fe5\u3002<\/p>\n 4<\/p>\n<\/section>\n<\/section>\n<\/section>\n \u603b\u7ed3\u4e0e\u8ba8\u8bba<\/strong><\/p>\n<\/section>\n<\/section>\n \u6742\u8d28\u7684\u7814\u7a76\u8d2f\u7a7f\u4e8e\u836f\u7269\u7814\u53d1\u7684\u59cb\u7ec8\uff0c\u5728\u836f\u7269\u7684\u6574\u4e2a\u751f\u547d\u5468\u671f\u9700\u8981\u4e0d\u65ad\u66f4\u65b0\u3002<\/p>\n \u6709\u673a\u6742\u8d28\u662f\u5316\u5b66\u836f\u7269\u6742\u8d28\u7684\u4e3b\u8981\u6765\u6e90\u4e4b\u4e00\uff0c\u6709\u673a\u6742\u8d28\u7684\u63a7\u5236\u4e5f\u662f\u76ee\u524d\u4eff\u5236\u53d1\u4e2d\u7684\u91cd\u70b9\u548c\u96be\u70b9\u3002<\/p>\n \u968f\u7740\u8d28\u91cf\u63a7\u5236\u7406\u5ff5\u7684\u53d8\u5316\uff0c\u201c\u8d28\u91cf\u6e90\u4e8e\u8bbe\u8ba1\u201d\u7684\u7406\u5ff5\u5df2\u88ab\u5e7f\u6cdb\u7684\u8ba4\u53ef\u548c\u91c7\u7eb3\uff0c\u6742\u8d28\u7684\u63a7\u5236\u5df2\u4e0d\u80fd\u5355\u7eaf\u4f9d\u8d56\u4e8e\u8d28\u91cf\u6807\u51c6\u4e2d\u7684\u6709\u5173\u7269\u8d28\u68c0\u67e5\u3002<\/p>\n \u672c\u6587\u4ee5\u787c\u66ff\u4f50\u7c73\u3001\u5730\u897f\u4ed6\u6ee8\u548c\u76d0\u9178\u5409\u897f\u4ed6\u6ee8\u4e3a\u4f8b\uff0c\u63a2\u8ba8\u4e86\u6709\u673a\u6742\u8d28\u5206\u6790\u7684\u63a7\u5236\u7684\u57fa\u672c\u601d\u8def\uff0c\u4f46\u5e76\u4e0d\u80fd\u6db5\u76d6\u5176\u6240\u6709\u7684\u6709\u673a\u6742\u8d28\u3002<\/p>\n \u4e0d\u540c\u7684\u4f01\u4e1a\u548c\u7814\u7a76\u8005\u5e94\u5145\u5206\u4e86\u89e3\u81ea\u8eab\u4ea7\u54c1\u7279\u70b9\uff0c\u5efa\u7acb\u5b8c\u5584\u7684\u6742\u8d28\u63a7\u5236\u4f53\u7cfb\uff0c\u5236\u5b9a\u5408\u7406\u7684\u6742\u8d28\u63a7\u5236\u7b56\u7565\uff0c\u5b9e\u73b0\u201c\u5168\u7a0b\u63a7\u5236\u201d\uff0c\u4ee5\u5145\u5206\u4fdd\u969c\u836f\u7269\u7684\u5b89\u5168\u3001\u6709\u6548\u548c\u8d28\u91cf\u53ef\u63a7\u3002<\/p>\n<\/section>\n \u53c2\u8003\u6587\u732e<\/strong><\/p>\n<\/section>\n \u8be6\u89c1 \u4e2d\u56fd\u65b0\u836f\u6742\u5fd7 2019 \u5e74\u7b2c28 \u5377\u7b2c11 \u671f<\/p>\n<\/section>\n \u514d\u8d23\u58f0\u660e<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n \u672c\u516c\u4f17\u53f7\u53d1\u5e03\u7684\u6587\u7ae0\u5747\u4e3a\u4fc3\u8fdb\u5236\u836f\u754c\u540c\u884c\u7684\u4ea4\u6d41\u4e0e\u5b66\u4e60\uff1b\u672a\u7528\u4e8e\u4efb\u4f55\u5546\u4e1a\u7528\u9014\u3002\u6211\u4eec\u5c0a\u91cd\u539f\u521b\u4f5c\u54c1\u3002\u9009\u53d6\u7684\u6587\u7ae0\u5df2\u660e\u786e\u6ce8\u660e\u6765\u6e90\u548c\u4f5c\u8005\uff0c\u7248\u6743\u5f52\u539f\u4f5c\u8005\u6240\u6709\uff0c\u5982\u6d89\u53ca\u4fb5\u6743\u6216\u5176\u4ed6\u95ee\u9898\uff0c\u8bf7\u8054\u7cfb\u6211\u4eec\u8fdb\u884c\u5220\u9664\u3002<\/strong><\/p>\n \u5185\u5bb9\u7531\u5c0f\u7f16\u67e5\u9605\u6587\u732e\u9009\u53d6\uff0c\u6392\u7248\u4e0e\u7f16\u8f91\u4e3a\u539f\u521b\u3002\u5982\u8f6c\u8f7d\uff0c\u8bf7\u5c0a\u91cd\u52b3\u52a8\u6210\u679c\uff0c\u6ce8\u660e\u6765\u6e90\u4e8e\u516c\u4f17\u53f7\u3002<\/p>\n \u6587\u7ae0\u5185\u5bb9\u4e3a\u4f5c\u8005\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u672c\u516c\u4f17\u53f7\u7acb\u573a\u3002<\/p>\n<\/section>\n \u5316\u5b66\u4eff\u5236\u836f\u6709\u673a\u6742\u8d28\u5206\u6790\u548c\u63a7\u5236\u5b9e\u4f8b\u89e3\u6790 \u6765\u6e90 \u4e2d\u56fd\u65b0\u836f\u6742\u5fd7 2019 \u5e74\u7b2c28 \u5377\u7b2c11 […]<\/p>\n","protected":false},"author":1,"featured_media":123268,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/123267"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=123267"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/123267\/revisions"}],"predecessor-version":[{"id":123284,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/123267\/revisions\/123284"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/123268"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=123267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=123267"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=123267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/section>\n
<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/p>\n
<\/section>\n
<\/section>\n
<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/p>\n
<\/section>\n
<\/section>\n
<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/p>\n
<\/section>\n
<\/section>\n
<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/p>\n
<\/section>\n
<\/section>\n
<\/section>\n
<\/section>\n<\/section>\n<\/section>\n\n\n
\n
<\/td>\n\n
<\/strong><\/p>\n<\/section>\n<\/td>\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/p>\n
<\/p>\n<\/section>\n
<\/p>\n
<\/section>\n<\/section>\n<\/section>\n<\/p>\n
<\/section>\n<\/section>\n<\/section>\n<\/p>\n<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/p>\n
<\/section>\n
<\/section>\n
<\/section>\n
<\/section>\n<\/section>\n<\/section>\n
<\/section>\n
<\/section>\n
<\/section>\n
<\/section>\n<\/section>\n<\/section>\n
<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"